A Three-dimensional Deformable Brain Atlas for DBS Targeting. I. Methodology for Atlas Creation and Artifact Reduction.

BackgroundTargeting in deep brain stimulation (DBS) relies heavily on the ability to accurately localize particular anatomic brain structures. Direct targeting of subcortical structures has been limited by the ability to visualize relevant DBS targets.Methods and resultsIn this work, we describe the development and implementation, of a methodology utilized to create a three dimensional deformable atlas for DBS surgery. This atlas was designed to correspond to the print version of the Schaltenbrand-Bailey atlas structural contours. We employed a smoothing technique to reduce artifacts inherent in the print version.ConclusionsWe present the methodology used to create a three dimensional patient specific DBS atlas which may in the future be tested for clinical utility

A Three-dimensional Deformable Brain Atlas for DBS Targeting. I. Methodology for Atlas Creation and Artifact Reduction.

BackgroundTargeting in deep brain stimulation (DBS) relies heavily on the ability to accurately localize particular anatomic brain structures. Direct targeting of subcortical structures has been limited by the ability to visualize relevant DBS targets.Methods and resultsIn this work, we describe the development and implementation, of a methodology utilized to create a three dimensional deformable atlas for DBS surgery. This atlas was designed to correspond to the print version of the Schaltenbrand-Bailey atlas structural contours. We employed a smoothing technique to reduce artifacts inherent in the print version.ConclusionsWe present the methodology used to create a three dimensional patient specific DBS atlas which may in the future be tested for clinical utility

Rapid fabrication of custom patient biopsy guides

Image-guided surgery is currently performed using frame-based as well as frameless approaches. In order to reduce the invasive nature of stereotactic guidance and the cost in both equipment and time required within the operating room, we investigated the use of rapid prototyping (RP) technology. In our approach, we fabricated custom patient-specific face masks and guides that can be applied to the patient during stereotactic surgery. While the use of RP machines has previously been shown to be satisfactory from an accuracy standpoint, one of our design criteria – completing the entire build and introduction into the sterile field in less than two hours – was unobtainable. (1) Our primary problems were the fabrication time and the nonresistance of the built material to high-temperature sterilization. In the current study, we have investigated the use of subtractive rapid prototyping (SRP) machines to perform the same quality of surgical guidance, while improving the fabrication time and allowing for choosing materials suitable for sterilization. Because SRP technology does not offer the same flexibility as RP in terms of prototype shape and complexity, our software program was adapted to provide new guid

Multi-Material Soft Matter Robotic Fabrication: A Proof of Concept in Patient-Specific Neurosurgical Surrogates

Soft matter 3D printing provides the capability to fabricate 3D structures by depositing hydrogel inks in granular gel support material. To date, there has been little work reported using this method to fabricate complex-shaped models with multiple materials in a timely fashion. The aim of this project is to introduce recent research of multi-material soft-matter extrusion and deposition for fast freeform fabrication of 3D structures, and to present a process for automating the fabrication of patient-specific neuro-anatomic models for surgical training. A compact design of multi-material extrusion printhead is described, which is capable of fabricating 3D structures from multiple inks. This approach provides a fast and efficient way to convert a virtual volumetric model into a physical extruded hydrogel structure using the multi-material soft-matter robotic fabrication system. In addition to fabrication of neurosurgical phantoms, the capabilities we describe may be useful in broader application contexts such as general soft matter robotic fabrication, pharmaceutical testing, and extrusion-based bioprinting.Mechanical Engineerin

Repeat single-fraction stereotactic radiosurgery for recurrent vestibular schwannoma

Background: Data are scarce on the efficacy of a second radiosurgery (SRS) treatment of vestibular schwannoma that has progressed following initial treatment with SRS. We sought to report the outcome of our repeat SRS series with long-term imaging follow-up. Materials and methods: We retrospectively analyzed 6 patients who met the following criteria: Repeat SRS at our institution between 1995 and 2018; solitary unilateral tumor; no evidence of neurofibromatosis; and magnetic resonance (MR) planning for both SRS treatments. All treatments were delivered with a linear accelerator-based system using head frame immobilization. The prescribed dose to the periphery of the tumor was 12.5 Gy in all initial and repeat SRS treatments, except for one repeat treatment to 10 Gy. Results: Follow-up with MR scan following the second SRS treatment was a median 8.4 years. The tumor control rate (lack of progression) following the second SRS treatment was 83% (5/6). Actuarial 10-year outcomes following repeat SRS were: tumor control, 80%; absolute survival, 80%; and cause-specific survival, 100%. Of the patients with at least minimal hearing retention before initial SRS, none had ipsilateral hearing preservation after initial radiation treatment. Improvement in any pretreatment cranial nerve deficits was not seen. The only permanent grade ≥ 3 toxicity from repeat SRS was a case of infraorbital nerve deficit. No patient developed a stroke, malignant transformation, induced second tumor, or facial nerve deficit. Conclusion: There was excellent overall survival, tumor control, and low morbidity in our series for recurrent vestibular schwannoma submitted to repeat single-fraction SRS, supporting additional studies of this treatment strategy